Is ethyl acetate (CAS 141 78 6) a class 3 solvent?

Yes, ethyl ethanoate/ethyl acetate (CAS 141-78-6) is classified as a Class 3 residual solvent under the ICH (International Council for Harmonisation) Q3C guidelines and USP.

What is a Class 3 solvent?

According to ICH Q3C (Residual Solvents Guidance): Class 3 solvents are low-toxicity solvents, considered safer, and suitable for pharmaceutical applications. Class 3 solvents are preferred when concentrations are higher than Class 1 or Class 2 solvents, and when minimizing toxicity is required and stricter controls are not necessary compared to Class 1 (highly toxic) or Class 2 (toxic) solvents.

CAS 141-78-6 Ethyl Acetate Solvent Classification

• ICH Q3C Classification: Class 3
• 50 mg/day (typical guideline)

Ethyl acetate is widely used as a residual solvent in pharmaceutical manufacturing and food-grade applications.

Applications of Class 3 Ethyl Acetate Solvent 

1. Paints, Coatings, and Inks

Largest consuming industry (especially in Asia). Ethyl acetate serves as a fast-evaporating solvent in paints, varnishes, and inks, enabling rapid drying and suitable for high-speed printing and spraying.

2. Adhesives and Packaging
Used in adhesives, sealants, and flexible packaging. Can be made into strong adhesives and fast-drying inks for packaging films/foils.

3. Pharmaceuticals and Cosmetics
Accounts for approximately 8-10% of global demand. Used in pharmaceutical purification; used in nail care and perfumes, characterized by rapid evaporation.

4. Food and Beverages
Used for caffeine and flavor extraction. Small amounts are safe for use as a fruit flavoring agent.

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